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Staff with underlying health conditions - Working with MDR patients

I have recently started work in a veterinary hospital as the infection prevention manager. Our animal patients on occasion can acquire multi-drug resistant infections amongst other infectious diseases such as leptospirosis, mycobacterial disease etc. We have members of staff that have underlying health conditions that means they feel they may be immunosuppressed. How do others go about risk assessing these staff members to ensure they are safe to work with these patients? (or determine the patients that it is not safe for them to be involved with their care?) We have full PPE including water resistant boiler suits, aprons, long cuff gloves, surgical face mask and foot covers within our isolation unit to protect staff and a strict hand hygiene policy. 
Many thanks for your input.

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